neutrophil elastase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9964	BOS-318		Others
	BOS-318 is a Furin inhibitor with slowly dissociating, highly selective, and cell-pemeable characteristcs.		Others
T79397	Neutrophil elastase inhibitor 4
	Neutrophil elastase inhibitor 4 (compound 4f) is a competitive inhibitor of human neutrophil elastase (HNE) with IC50 of 42.30 nM and Ki of 8.04 nM. It prompts apoptosis in T47D cells and inhibits the proliferation of T4...
T13389	ZD-0892		PI3K
	ZD-0892 is a selective and poten neutrophil elastaset inhibitor(human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 and 200 nM, respectively).		PI3K
T3107	Alvelestat	AZD9668,Avelestat	Others , Serine Protease
	Alvelestat (AZD9668) is an orally bioavailable, selective and reversible inhibitor of human neutrophil elastase (NE), with potential anti-inflammatory activity.		Others , Serine Protease
T6986	Sivelestat	ONO5046,EI546,LY544349	Others , SARS-CoV , Serine Protease
	Sivelestat (ONO5046) is a potent and selective inhibitor of neutrophil elastase with IC50 of 44 nM.		Others , SARS-CoV , Serine Protease
T12613L	BAY-85-8501		Serine Protease
	BAY-85-8501 is a selective, reversible and potent inhibitor of Human Neutrophil Elastase (HNE; IC50 of 65 pM)		Serine Protease
T8563	2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one		Serine Protease
	2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one is an human neutrophil elastase inhibitor.		Serine Protease
T8602	2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA6-BENZO[D]ISOTHIAZOL-3-ONE		Serine Protease
	2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA6-BENZO[D]ISOTHIAZOL-3-ONE targets the Neutrophil elastase (human).		Serine Protease
T68099	Midesteine	MR-889	Others
	Midesteine (MR-889) is a small molecule neutrophil elastase inhibitor used in the treatment of bronchitis, asthma and chronic lung disease.		Others
TJS0314	5,7-Dihydroxy-4-methylcoumarin	Methyl-2H-Chromen-2-One,4-Methyllimetol,4-Methyl-5,7-Dihydroxycoumarin	Others , Antibacterial , Antifungal
	5,7-Dihydroxy-4-methylcoumarin (Methyl-2H-Chromen-2-One) inhibits human neutrophil oxidative metabolism and elastase activity. 5,7-Dihydroxy-4-methylcoumarin has in vitro platelet antiaggregatory property. 5,7-Dihydroxy-...		Others , Antibacterial , Antifungal
T10473	BAY-678		Others
	BAY-678 is a human neutrophil elastase (HNE; IC50: 20 nM) inhibitor with oral bioactivity, potency and selectivity.BAY-678 is a chemical probe recommended by the Structural Genomics Consortium (SGC).		Others
T25131	AZD8309	AZD 8309,AZD-8309	Glutathione Peroxidase , CXCR
	AZD8309 is a potent, orally available antagonist of the chemokine receptor CXCR2 that regulates neutrophil transport, significantly reduces MPO in the pancreas and lung, and decreases trypsin and elastase activity in the...		Glutathione Peroxidase , CXCR
T20762	Sivelestat sodium tetrahydrate	ONO-5046 sodium tetrahydrate,Elaspol,ONO 5046,ONO5046 sodium tetrahydrate,Elaspol sodium tetrahydrate,ONO-5046,Sivelestat Sodium,Sivelestat Sodium Hydrate,ONO5046	Serine Protease
	Sivelestat sodium tetrahydrate (ONO5046 sodium tetrahydrate) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for...		Serine Protease
T15285	FK706		Serine Protease
	FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively)...		Serine Protease
T17288	ZD8321		Serine Protease
	ZD8321 is an effective inhibitor of human Neutrophil elastase (Ki: 13±1.7 nM).		Serine Protease
T10254	AE-3763		Serine Protease
	AE-3763 is a peptide-based human neutrophil elastase inhibitor (IC50: 29 nM).		Serine Protease
T31877	Freselestat	ONO-PO 736,ONO-6818,ONO 6818,ONO6818
	Freselestat (ONO-6818) is a potent neutrophil elastase inhibitor that significantly reduces the production of interleukin 8 and C5B-9. Freselestat reduces inflammatory mediators during simulated cardiopulmonary bypass.
T25520	ICI 200355	ICI-200,355,ICI 200,355,ICI-200355,ICI200,355,ICI200355
	ICI 200355 is an inhibitor of human neutrophil elastase.
T25781	MDL 101146	MDL-101146,MD 101,146,MDL101146,MDL 101,146,MDL-101,146
	MDL 101146 is an orally active neutrophil elastase inhibitor.
T25521	Ici 200880	Ici 200,880,Ici-200880,Ici200,880,Ic-200,880,Ici200880
	Ici 200880 is a human neutrophil elastase synthetic peptide inhibitor.